Christel Krueger

This study shows that maternal SMARCA5 is essential for major ZGA in mouse embryos by regulating promoter and distal regulatory region accessibility and nucleosome positioning.

The paper investigates how DNA methylation dynamics during pluripotency exit influence enhancer priming and hematopoietic gene activation in mouse cells.

The paper shows NANOGP1, a duplicate of NANOG, has partial functional conservation in human naive pluripotent stem cells, contributing to pluripotency but not maintaining undifferentiated status.

The paper examines how MEK and GSK3 inhibition affects the methylome and transcriptome of mouse embryonic stem cells, revealing distinct epigenetic and transcriptional changes.

The paper analyzes promoter interactions in human pluripotent states to reveal hierarchical differences in genome organization using a network-graph approach.

This study identifies Dppa2/4 as epigenetic factors that establish bivalency at developmental promoters, enabling lineage commitment by maintaining poised RNA polymerase and preventing DNA methylation.

This study identifies Dppa2 and Dppa4 as upstream regulators of the Dux-driven zygotic transcriptional programme in 2C-like cells.

The paper uses single cell triple-omics analysis to reveal how epigenetic changes drive germ layer specification in mouse embryos, showing distinct epigenetic priming and remodeling in different lineages.

This study shows that H3K4me3 is essential for maintaining normal gene expression levels across yeast lifespan, with COMPASS mutations reducing lifespan and causing gene expression defects.

This paper shows TET3 promotes open chromatin and enhances global transcription in embryonic stem cells, independent of its catalytic activity.