Obada R. Shamaa

Transfer Learning Enables Drug-Target Interaction Prediction in Data-Scarce One-Carbon Metabolism

The paper uses transfer learning to predict drug-target interactions for mitochondrial one-carbon metabolism enzymes with limited data, identifying potential repurposable drugs.

Role of Arginine and its Metabolism in TGF-β-Induced Activation of Lung Fibroblasts

This study investigates the role of arginine and its metabolism in TGF-β-induced activation of lung fibroblasts, finding that arginine depletion inhibits mTORC1 activation and collagen production.

HIF-1α regulates mitochondrial function in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages

The paper shows HIF-1α regulates glycolytic shifts and mitochondrial function differently in bone marrow-derived macrophages compared to tissue-resident alveolar macrophages.

ATF4 and mTOR regulate metabolic reprogramming in TGF-β-treated lung fibroblasts

This study investigates how ATF4 and mTOR regulate metabolic reprogramming in TGF-β-treated lung fibroblasts, identifying their roles in amino acid homeostasis and glycolytic pathways.