Robert B. Hamanaka

Lifecourse sex-specific molecular response to early-life exposures of toxic substances

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

Transfer Learning Enables Drug-Target Interaction Prediction in Data-Scarce One-Carbon Metabolism

The paper uses transfer learning to predict drug-target interactions for mitochondrial one-carbon metabolism enzymes with limited data, identifying potential repurposable drugs.

Comprehensive Transcriptomic and Epigenomic Insights into Environmental Toxicant Exposures: The TaRGET II Resource

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

Role of Arginine and its Metabolism in TGF-β-Induced Activation of Lung Fibroblasts

This study investigates the role of arginine and its metabolism in TGF-β-induced activation of lung fibroblasts, finding that arginine depletion inhibits mTORC1 activation and collagen production.

HIF-1α regulates mitochondrial function in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages

The paper shows HIF-1α regulates glycolytic shifts and mitochondrial function differently in bone marrow-derived macrophages compared to tissue-resident alveolar macrophages.

ATF4 and mTOR regulate metabolic reprogramming in TGF-β-treated lung fibroblasts

This study investigates how ATF4 and mTOR regulate metabolic reprogramming in TGF-β-treated lung fibroblasts, identifying their roles in amino acid homeostasis and glycolytic pathways.

Critical role of Gα12 and Gα13 proteins in TGF-β-induced myofibroblast differentiation.

This study shows that Gα12 and Gα13 proteins are essential for TGF-β-induced myofibroblast differentiation by regulating Smad phosphorylation and receptor expression.

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis

Single-cell RNA-seq of lung tissue from transplant donors, fibrosis patients, and a living patient identifies cell type-specific disease-associated molecular pathways in pulmonary fibrosis.