A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance
Ya’ara Negev-Korem, Esther Stern, Hadar Golan-Berman, Elisheva E. Heilbrun, Subhendu Karmakar, Yoram Soroka, Marina Frušić‐Zlotkin, Ofer Chen, Hiba Hassanain, Ori Wald, Dan Gibson, Ron Kohen, Sheera Adar
This study develops a novel cisplatin-based prodrug that inhibits lysine deacetylases and suppresses nucleotide excision repair, enhancing cisplatin's cytotoxicity and overcoming resistance.
bioRxiv · Oct 30, 2024 · PreprintMolecular Biology