Severe neural tube defects due to failure of closure initiation can arise without abnormality of neuroepithelial convergent extension
Oleksandr Nychyk, Gabriel L. Galea, Matteo A. Molè, Dawn Savery, Nicholas D. E. Greene, Philip Stanier, Andrew J. Copp
The paper shows that severe neural tube defects can occur without abnormal convergent extension by linking GAG sulfation and partial PCP gene loss.
bioRxiv · Jul 4, 2021 · PreprintDevelopmental Biology