Matteo A. Molè

Endometrial assembloids of gland organoids and stromal cells reproduce midluteal cell states by scRNA-seq. Senescent decidual cells, tuned with dasatinib, track with whether co-cultured human blastocysts expand or stall.

The paper shows that severe neural tube defects can occur without abnormal convergent extension by linking GAG sulfation and partial PCP gene loss.

This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.

The paper shows that neuro-mesodermal progenitors in mice express T/Brachyury but not Sox2, challenging the hypothesis that they co-express both markers.