Nicholas D. E. Greene

Extracellular matrix defects destabilise apical cytoarchitecture and mechanical properties during early Down syndrome neurodevelopment

This study shows that ECM defects in Down syndrome neurodevelopment cause apical cytoarchitecture and mechanical property instability in neural stem cell models.

Chiari II brain malformation is secondary to open spina bifida

The paper demonstrates that Chiari II brain malformation arises secondary to open spina bifida in mice, showing structural brain and skull defects linked to neurogenesis and neuronal migration disturbances.

Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism

The paper shows ATF4 rewires mitochondrial one-carbon metabolism during infection to restrict Toxoplasma growth via folate competition.

Spinal neural tube formation and tail development in human embryos

This study examines spinal neural tube formation and tail development in human embryos, finding patterns similar to mouse and rat, including primary neurulation completion and secondary neurulation characteristics.

AAV-mediated expression of mouse or human GLDC normalises metabolic biomarkers in a GLDC-deficient mouse model of Non-Ketotic Hyperglycinemia

This study demonstrates that AAV-mediated GLDC expression reduces glycine levels and normalizes folate metabolism in a GLDC-deficient mouse model of NKH.

CFL1-dependency of discrete cell behaviours driving mouse spinal zippering

This study identifies CFL1-dependent cell behaviours driving spinal zippering in mice and shows that its deletion impairs zippering and causes spina bifida.

Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice

This study shows that disrupting Fgfr1 in mice causes localized spinal mis-patterning and a terminal myelocystocele-like phenotype after neural tube closure.

Severe neural tube defects due to failure of closure initiation can arise without abnormality of neuroepithelial convergent extension

The paper shows that severe neural tube defects can occur without abnormal convergent extension by linking GAG sulfation and partial PCP gene loss.

Hindbrain neuropore tissue geometry determines asymmetric cell-mediated closure dynamics

The paper shows that the geometry of the hindbrain neuropore in mouse embryos determines asymmetric closure dynamics through cell-mediated mechanisms.

Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects

This paper introduces a novel mouse model of encephalocele showing it arises post-neurulation and can share genetic causes with anencephaly.

Genetic approaches in mice demonstrate that neuro-mesodermal progenitors express T/Brachyury but not Sox2

The paper shows that neuro-mesodermal progenitors in mice express T/Brachyury but not Sox2, challenging the hypothesis that they co-express both markers.