siRNA biogenesis, DNA methylation and target locus silencing are distinct and separable Pol IV sub-functions differentially dependent on the largest subunit's CTD
Jered M. Wendte, Jeremy R. Haag, Olga Pontes, Jasleen Singh, Sara Metcalf, Craig S. Pikaard
The paper shows that the CTD of NRPD1 is critical for siRNA production and target locus silencing but not for DNA methylation, indicating distinct roles for Pol IV in RdDM.
Nucleic Acids Research · Jul 5, 2019Peer-reviewedMolecular Biology