Author

Sara Metcalf

Indiana University Bloomington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Organism:plant (other)· 1 Organism:yeast· 1

Frequent Co-Authors

Alicia BaoiD· 1 shared Anita K. HopperiD· 1 shared Craig S. PikaardiD· 1 shared Jasleen Singh· 1 shared Jered M. WendteiD· 1 shared Jeremy R. Haag· 1 shared Katherine Clark· 1 shared Olga Pontes· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

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2 papers

Recent·Most cited

MANY PATHS TO DESTRUCTION: FAMILY-SPECIFIC TURNOVER AND STRESS RESPONSES FOR TRNA INTRONS

Sara Metcalf, Regina Nostramo, Alicia Bao, Katherine Clark, Paolo L Sinopoli, Anita K. Hopper

The paper investigates the regulation of tRNA intron levels across different organisms and environmental conditions, revealing family-specific turnover mechanisms and stress responses.

Proceedings of the National Academy of Sciences · Apr 10, 2026Peer-reviewedMolecular Biology

siRNA biogenesis, DNA methylation and target locus silencing are distinct and separable Pol IV sub-functions differentially dependent on the largest subunit's CTD

Jered M. Wendte, Jeremy R. Haag, Olga Pontes, Jasleen Singh, Sara Metcalf, Craig S. Pikaard

The paper shows that the CTD of NRPD1 is critical for siRNA production and target locus silencing but not for DNA methylation, indicating distinct roles for Pol IV in RdDM.

Nucleic Acids Research · Jul 5, 2019Peer-reviewedMolecular Biology