Aneuploidy of Specific Chromosomes is Beneficial to Cells Lacking Spindle Checkpoint Protein Bub3
Pallavi Gadgil, Olivia Ballew, Timothy J. Sullivan, Soni Lacefield
This study shows that cells lacking Bub3, a spindle checkpoint protein, retain specific chromosomes through aneuploidy, which provides a survival advantage by increasing the expression of genes involved in chromosome segregation.
PLoS Genetics · Feb 4, 2025Peer-reviewedCell Biology