Requirement of hypoxia-inducible factor 1 alpha for interleukin 1 beta induced glycolysis in colorectal cancer cells
Ji Yeon Kim, Bohye Park, Olivia F. Riffey, Ahmed Bettaieb, Dallas R. Donohoe
This study shows that IL-1β increases glycolysis and inhibits butyrate oxidation in colorectal cancer cells via AKT and HIF1 activation, promoting cancer progression.
bioRxiv · Aug 19, 2026 · PreprintCell Biology