NeurosciencebioRxivPreprint
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
Carmelo Milioto, Mireia Carcolé, Ashling Giblin…·Adrian M. Isaacs
The paper generates C9orf72 DPR knock-in mice and identifies an extracellular matrix signature in C9ALS/FTD that is conserved across species and protected by TGF-β1 and COL6A1.
DOI 10.1101/2023.07.17.549331