PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia N. Attrebi, Mhoriam Ahmed, Sam Harris, Byung Il Lee, Mengke Yang, Raja Sekhar Nirujogi, Daniel Biggs, Sally E. Salomonsson, Matteo Zanovello, Paula De Oliveira, Eszter Katona, , Adrian M. Isaacs
The paper generates C9orf72 DPR knock-in mice and identifies an extracellular matrix signature in C9ALS/FTD that is conserved across species and protected by TGF-β1 and COL6A1.
bioRxiv · Jul 17, 2023 · PreprintNeuroscience