Molecular mechanism of action of a blood brain barrier shuttle antibody
Sulin Liu, Ollie King, Ayla A. Wahid, Chuhan Shang, Luke A. Pattison, Tomas Malinauskas, Eduardo A. Santander, Stephanie A. Nestorow, Wan-Na Chen, Vasiliki Mavridou, Jacob I Browne, Ewan St. John Smith, John E. Linley, Carl I. Webster, Paul S. Miller
This study determines the cryo-EM structure of a brain shuttle antibody bound to the transferrin receptor and shows how its binding features affect avidity, pH sensitivity, and brain delivery.
bioRxiv · Jul 5, 2026 · PreprintNeuroscience