Carl I. Webster

This study determines the cryo-EM structure of a brain shuttle antibody bound to the transferrin receptor and shows how its binding features affect avidity, pH sensitivity, and brain delivery.

The paper discovers a novel thermostable monomeric meganuclease from metagenomic data with unique DNA recognition and cleavage properties.

This study demonstrates that systemic delivery of ASO conjugated to a brain-targeting antibody improves SMN2 splicing and survival in SMA mouse models.