Paul S. Miller

Molecular mechanism of action of a blood brain barrier shuttle antibody

This study determines the cryo-EM structure of a brain shuttle antibody bound to the transferrin receptor and shows how its binding features affect avidity, pH sensitivity, and brain delivery.

A robust platform for recombinant production of animal venom toxin modulators of ion channels

This paper develops a method to produce animal venom toxins using recombinant Fc-fusion proteins, achieving high yields and functionality for various toxin types.

Heteromeric GABAA receptor structures in positively-modulated active states

The paper reports cryo-EM and crystal structures of GABAA receptors with ligands, revealing the molecular basis of BZD modulation.