Driving proteomic imbalance in malignancy provokes proteomic catastrophe and confers tumor suppression
Babul Moni Ram, Omprakash Shriwas, Meng Xu, Kun-Han Chuang, Chengkai Dai
This study shows that loss of HSF1 in MPNST cells causes proteomic imbalance and tumor suppression by inducing proteomic catastrophe through amyloidogenesis and mTORC1 inhibition.
bioRxiv · May 24, 2024 · PreprintCancer Biology