Author

Chengkai Dai

National Cancer InstituteORCID 0000-0001-8520-1036Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Babul Moni RamiD· 1 shared Kun-Han Chuang· 1 shared Kun‐Han ChuangiD· 1 shared Ling Lin· 1 shared Meng Xu· 1 shared Omprakash Shriwas· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperCancer Biology

Babul Moni RamORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 5, 2026

c-MYC is an aggregation-prone, amyloidogenic protein

Ling Lin, Kun‐Han Chuang, Chengkai Dai

This study identifies c-MYC as an amyloidogenic protein that forms oligomers and aggregates under stress and in cancer tissues, contributing to its tumor-suppressive activity through apoptosis.

DOI 10.64898/2026.03.12.711438

humanprotein structure

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Cancer BiologybioRxivPreprintMay 24, 2024

Driving proteomic imbalance in malignancy provokes proteomic catastrophe and confers tumor suppression

Babul Moni Ram, Omprakash Shriwas, Meng Xu…·Chengkai Dai

This study shows that loss of HSF1 in MPNST cells causes proteomic imbalance and tumor suppression by inducing proteomic catastrophe through amyloidogenesis and mTORC1 inhibition.

DOI 10.1101/2024.05.24.595838

mouseproteomics

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