Combined Loss of VHL and TSC1 Drives Clear Cell Renal Cell Carcinoma with Metabolic and Redox Reprogramming that Creates an NRF2 Dependency
Jianing Xu, Xiaoqing Cheng, Omran Abu Aboud, YingBei Chen, Ann Bialik, Ed Reznik, Toshinao Oyama, Satish K. Tickoo, Robert H. Weiss, Emily H. Y. Cheng, James J.-D. Hsieh
This study creates a mouse model of VHL-/-TSC1-/- ccRCC, identifies metabolic and redox reprogramming, and highlights NRF2 as a therapeutic target.
bioRxiv · Sep 28, 2026 · PreprintCancer Biology