Author

James J.-D. Hsieh

University of WashingtonORCID 0000-0003-3595-0551Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Ed ReznikiD· 2 shared A. Ari HakimiiD· 1 shared Alexander I. SankiniD· 1 shared Andrew WineriD· 1 shared Angela Yoo· 1 shared Ann BialikiD· 1 shared Benjamin FreemaniD· 1 shared Emily H. Y. ChengiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Ed ReznikORCID

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2 papers

Recent·Most cited

Combined Loss of VHL and TSC1 Drives Clear Cell Renal Cell Carcinoma with Metabolic and Redox Reprogramming that Creates an NRF2 Dependency

Jianing Xu, Xiaoqing Cheng, Omran Abu Aboud, YingBei Chen, Ann Bialik, Ed Reznik, Toshinao Oyama, Satish K. Tickoo, Robert H. Weiss, Emily H. Y. Cheng, James J.-D. Hsieh

This study creates a mouse model of VHL-/-TSC1-/- ccRCC, identifies metabolic and redox reprogramming, and highlights NRF2 as a therapeutic target.

bioRxiv · Sep 28, 2026 · PreprintCancer Biology

Resource-efficient pooled sequencing expands translational impact in solid tumors

Renzo G. DiNatale, Roy Mano, Vladimir Makarov, Nicole Rusk, Esther N Drill, Andrew Winer, Alexander I. Sankin, Angela Yoo, Benjamin Freeman, James J.-D. Hsieh, Ying‐Bei Chen, Jonathan Coleman, Michael Berger, Irina Ostrovnaya, Timothy An-thy Chan, , A. Ari Hakimi

This paper introduces a pooled sequencing strategy to address intratumoral genetic heterogeneity in cancer, showing it improves mutation detection and risk stratification while reducing costs.

Kidney Cancer Journal · Jun 21, 2021Peer-reviewedGenomics