Author

Jianing Xu

Memorial Sloan Kettering Cancer CenterPrimary ORCID profile (0000-0003-2547-4344 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jianing XuiD1 paper · Shandong University

Biology Disciplines

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Cancer Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alexander Edward Dela Cruz DriloniD· 1 shared Ann BialikiD· 1 shared Corina AmoriD· 1 shared Douglas Warner· 1 shared Ed ReznikiD· 1 shared Elisa de StanchinaiD· 1 shared Emily H. Y. ChengiD· 1 shared Ezra Y. RoseniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Alexander Edward Dela Cruz DrilonORCID

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3 papers

Recent·Most cited

Combined Loss of VHL and TSC1 Drives Clear Cell Renal Cell Carcinoma with Metabolic and Redox Reprogramming that Creates an NRF2 Dependency

Jianing Xu, Xiaoqing Cheng, Omran Abu Aboud, YingBei Chen, Ann Bialik, Ed Reznik, Toshinao Oyama, Satish K. Tickoo, Robert H. Weiss, Emily H. Y. Cheng, James J.-D. Hsieh

This study creates a mouse model of VHL-/-TSC1-/- ccRCC, identifies metabolic and redox reprogramming, and highlights NRF2 as a therapeutic target.

bioRxiv · Sep 28, 2026 · PreprintCancer Biology

A stem cell aging clock links biological age deviation to clinical outcome in acute myeloid leukemia

Hongcheng Chen, Pengwei Dong, Jianing Xu, Guanlin Wang

The paper develops a stem cell aging clock using single-cell transcriptomics to predict clinical outcomes in AML by measuring transcriptional age deviation.

bioRxiv · Mar 18, 2026 · PreprintSystems Biology

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

Jacob A. Boyer, Ezra Y. Rosen, Malvika Sharma, Madeline A. Dorso, Nicholas Mai, Corina Amor, Jason Reiter, Ram Kannan, Sunyana Gadal, Jianing Xu, Matthew M. Miele, Zhuoning Li, Xiaoping Chen, Qing Chang, Fresia G. Pareja, , Neal X. Rosen

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

Proceedings of the National Academy of Sciences · Jul 21, 2025Peer-reviewedCancer Biology