Zinc Differentially Modulates Tau Aggregation, Fibril Morphology, and Prion-like Seeding in a Construct-Dependent Manner
Emma L. Poirier, Alyssa Stainton, Oskar Simon, Suhana S. Mittal, Ana B. Varona Ortiz, Sally A. Kim, Jennifer N. Rauch
This study shows zinc modulates tau aggregation and seeding differently based on tau sequence context, highlighting cofactor effects depend on sequence and conformational constraints.
bioRxiv · Jul 2, 2026 · PreprintBiochemistry