Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
Mahshid Mohammadi, Muzaffer Ahmed Bhat, T. Li, Ning Wei, Priyanka Patil, Christiana Mo, Natalie Thielen, Zimo Huang, Juan Du, Doctor Yitzchak Goldstein, Othon Wiltz, Renee Huang, Kohtaro Ooka, Melanie Quintal, Edward Chu, Chaoyuan Kuang
This study evaluates CDK9 inhibitors in CRC models, showing potent anti-proliferative effects and synergy with MEK inhibitors, suggesting a potential combination therapy for CRC.
bioRxiv · Aug 13, 2025 · PreprintCancer Biology