Chaoyuan Kuang

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

This study identifies senescent fibroblasts in lung cancer stroma that alter tumor metabolism and plasticity, and shows that targeting these cells with XL888 reduces tumor burden.

Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer

This study evaluates CDK9 inhibitors in CRC models, showing potent anti-proliferative effects and synergy with MEK inhibitors, suggesting a potential combination therapy for CRC.

High Throughput Screening Identifies Small Molecules that Synergize with MRTX1133 Against Acquired Resistant KRAS G12D Mutated CRC