Cone outer segment renewal in vivo involves progressive particle formation at the photoreceptor-RPE interface
Noora Emilia Nevala, Jenni Susanna Partinen, Outi Liang, Tugce Ilayda Turer, Takeshi Yoshimatsu, Teemu O. Ihalainen, Soile Nymark
This study uses live imaging in zebrafish to show that cone outer segments are removed in small, successive particles at the cone-RPE interface without extracellular accumulation.
bioRxiv · Oct 25, 2026 · PreprintNeuroscience