Takeshi Yoshimatsu

Cone outer segment renewal in vivo involves progressive particle formation at the photoreceptor-RPE interface

This study uses live imaging in zebrafish to show that cone outer segments are removed in small, successive particles at the cone-RPE interface without extracellular accumulation.

Genome-wide association and multi-omics functional screens reveal the genetic architecture of foveal development

This paper identifies genetic variants and genes associated with foveal hypoplasia using GWAS and multi-omics data, and establishes a zebrafish model to study the condition.

Distinct Roles of CaMKII in Synaptic Vesicle Dynamics at Zebrafish Retinal Rod Bipolar Ribbon Synapses

This study manipulates CaMKII activity in zebrafish retinal rod bipolar cell ribbon synapses to show that both inhibition and elevation impair neurotransmitter release, suggesting optimal CaMKII levels are required for normal function.

Glia regulate local retinoic acid levels to specify neuronal specialisation for high-acuity vision

The paper shows that Muller glia regulate retinoic acid (RA) levels in zebrafish retina to control cone OS length and functional specialisation in the acute zone.

A heterogeneous population code at the first synapse of vision

This study measures the input-output relations of photoreceptors in zebrafish and finds functional heterogeneity in their response to visual stimuli.

Comparative transcriptomic insights into the evolutionary origin of the tetrapod double cone

The paper uses transcriptomic data from six vertebrate species to investigate the evolutionary origin of the tetrapod double cone, finding that both members originated from ancestral red cones and rods emerged before cone diversification.

Restoration of Cone Circuit Functionality in the Regenerating Adult Zebrafish Retina

The paper investigates functional recovery of regenerated cone photoreceptors in adult zebrafish retinas after light-induced injury, finding restored physiological circuit functionality within 3 months.

Ancient origin of the rod bipolar cell pathway in the vertebrate retina

The paper identifies two rod bipolar cell types in zebrafish that are related to mammalian rod bipolar cells, suggesting the primary rod pathway evolved over 400 million years ago.

Simple Models For Neuroscience Research Discoveries: How Often Are These Models Used In Africa

The paper analyzes the use of simple animal models in African research publications from 2000 to 2021, finding that South Africa, Nigeria, Kenya, Egypt, Morocco, and Tunisia contributed 75% of studies, with most studies having international collaborations.

The developmental progression of eight opsin spectral signals recorded from the zebrafish retinal cone layer is altered by the timing and cell type expression of thyroxin receptor β2 (trβ2) gain-of-function transgenes.

The paper analyzes how trβ2 transgenes alter opsin signaling in zebrafish retinas across development, showing different amplitude changes in larvae, juveniles, and adults.

Amacrine cells differentially balance zebrafish colour circuits in the central and peripheral retina

This study investigates how amacrine cells in zebrafish retinas differentially balance colour and greyscale processing in central and peripheral regions through distinct inhibitory circuits.

Spectral inference reveals principal cone-integration rules of the zebrafish inner retina

The paper uses spectral responses of bipolar cells in zebrafish to infer integration rules in the inner retina, revealing six dominant spectral motifs and a new axis of spectral opponency.

Distinct Synaptic Transfer Functions in Same-Type Photoreceptors

The paper shows that UV-cones in larval zebrafish eyes have distinct synaptic transfer functions based on their location, using a combination of imaging and modeling techniques.

Gaze stabilisation behaviour is anisotropic across visual field locations in zebrafish

The paper measures optokinetic response gain in zebrafish larvae across their visual field using a spherical LED arena and finds anisotropic responses consistent with retinal photoreceptor densities.

A high-density narrow-field inhibitory retinal interneuron with direct coupling to Müller glia

The paper identifies a new inhibitory retinal amacrine cell type, MAC, that forms direct electrical and chemical synapses with Müller glia, revealing neuron-glia coupling in the mammalian retina.

Ancestral circuits for vertebrate colour vision emerge at the first retinal synapse

The paper reveals how larval zebrafish retinal circuits process color by rotating spectral information into primary achromatic and chromatic axes at the first synapse, a strategy also used by fruit flies.

Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

This study shows that mutations in tr{beta}2 in zebrafish disrupt red-cone development and function, leading to colorblindness and shifts in cone contributions.

What the Zebrafish's Eye Tells the Zebrafish's Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

The paper characterizes retinal ganglion cells (RGCs) in larval zebrafish, revealing UV-responsive RGCs and complex color opponency, suggesting a dual-achromatic visual strategy for prey capture and color vision.

Divergent excitation two photon microscopy for 3D random access mesoscale imaging at single cell resolution

This paper introduces a new two-photon microscopy technique that expands the 3D field of view while maintaining single-cell resolution, enabling more comprehensive neuronal activity imaging in multiple organisms.

Cellular and molecular mechanisms of photoreceptor tuning for prey capture in larval zebrafish

The paper shows UV-cones in larval zebrafish are tuned for UV-bright prey capture through regional boosts in detection efficiency and synaptic calcium baseline.

Zebrafish differentially process colour across visual space to match natural scenes

This study shows larval zebrafish use anisotropic retinal circuits to process color asymmetrically across visual space, matching natural scene statistics.