Teemu O. Ihalainen

The paper uses imaging and modeling to study transient leaks in epithelial tight junctions, finding that dynamic strand breaking and sealing explain leak behavior at the junction level.

This study uses live imaging in zebrafish to show that cone outer segments are removed in small, successive particles at the cone-RPE interface without extracellular accumulation.

The paper identifies deep nuclear envelope invaginations (DINEs) in epithelial cells, showing they organize chromatin and gene activity in response to mechanical cues like crowding and tissue maturation.

This study shows that the nucleus softens during herpesvirus infection due to reduced outward forces and low biomolecular density in the viral replication compartment.

This study shows that substrate viscoelasticity influences how cells sense mechanical deformation through calcium signals, with stiff substrates producing stronger responses and distinct force dynamics.

This study develops a biomimetic hydrogel platform to model RPE-retina interactions, revealing actin-dependent force transduction during photoreceptor phagocytosis.

This study investigates how sex, mouse strain, and culturing conditions affect circadian rhythms in murine ocular tissues, finding that Neurobasal A medium and mouse strain enhance rhythms, while sex does not.

The paper shows that phagocytosis of cone outer segments in larval zebrafish varies by cone subtype, with UV and blue cones showing rhythmic peaks while green and red cones are phagocytosed more evenly.

The paper develops an iterative immunostaining method combined with expansion microscopy and image processing to enhance super-resolution imaging of nuclear lamina structures.