Single amino acid substitution in DNA Polymerase I dramatically alters infection dynamics of bacteriophage T7
Rachel A. Keown, Andrew P. Sikkema, Victoria Barbone, Barbra D. Ferrell, Owen Donnelly, Sydney Iredell, Kelly M. Zatopek, Phillip J. Brumm, David A. Mead, Gregory J. S. Lohman, K. Eric Wommack, Shawn W. Polson
This study shows that a single amino acid substitution in phage T7's DNA polymerase I significantly affects infection dynamics in the T7-E. coli system.
bioRxiv · May 21, 2026 · PreprintMicrobiology