A novel experimental system reveals immunoregulatory responses as mediators of persistent orthohantavirus infections in a rodent reservoir host
T. Strandin, T. Smura, P. Ahola, K. Aaltonen, T. Sironen, J. Hepojoki, I. Eckerle, R. Ulrich, O. Vapalahti, A. Kipar, K. Forbes
This study develops an experimental system to investigate immunoregulatory responses in bank voles infected with PUUV, revealing that virus-induced interleukin-10 promotes persistent infections by suppressing immune responses.
bioRxiv · Nov 5, 2019 · PreprintMicrobiology