J. Hepojoki

Unraveling human, rodent and snake Kolmioviridae replication to anticipate cross-species transmission

This study compares the replication of three Kolmioviridae viruses in vitro and in vivo, revealing differences in host range and replication efficiency.

Reptarenavirus Co- and Superinfection in Cell Culture Sheds Light on the S and L Segment Accumulation in Captive Snakes

This study investigates reptarenavirus co- and superinfection in cell cultures, finding no competition between closely related viruses but reduced replication of closely related segments in persistently infected cells.

Boid Inclusion Body Disease (BIBD) Is Also a Disease of Wild Boa Constrictors

This paper identifies reptarenavirus infection and Boid Inclusion Body Disease (BIBD) in wild and captive boa constrictors in Costa Rica, showing the disease occurs in wild populations and suggesting boas may contribute to natural virus circulation.

Intranasal inhibitor broadly blocks SARS-CoV-2 including recent highly immunoevasive Omicron subvariants

This paper describes a novel intranasal inhibitor, TriSb92, that effectively neutralizes SARS-CoV-2 and recent Omicron subvariants, offering protection against infection in mice.

Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system

This study shows that neuropilin-1 enhances SARS-CoV-2 infectivity and facilitates viral entry into the central nervous system via the olfactory pathway.

Experimental Reptarenavirus Infection of Boa constrictor and Python regius

This study experimentally infects pythons and boas with reptarenavirus via different routes, finding infection without inclusion bodies and suggesting other factors contribute to BIBD pathogenesis.

Identification of Reptarenaviruses, Hartmaniviruses and a Novel Chuvirus in Captive Brazilian Native Boa Constrictors with Boid Inclusion Body Disease

The paper identifies novel reptarenaviruses, hartmaniviruses, and a chuvirus in Brazilian captive boas with Boid Inclusion Body Disease using metatranscriptomic analysis.

Molecular rationale for hantavirus neutralization by a reservoir host-derived monoclonal antibody

This study investigates how a monoclonal antibody neutralizes hantaviruses by targeting the glycoprotein lattice, revealing structural insights into antibody binding and its impact on viral entry.

Python nidoviruses, more than respiratory pathogens

This study investigates python nidoviruses, finding they infect multiple tissues beyond the respiratory tract and spread systemically via monocytes, challenging previous understanding of their tropism and disease patterns.

A novel experimental system reveals immunoregulatory responses as mediators of persistent orthohantavirus infections in a rodent reservoir host

This study develops an experimental system to investigate immunoregulatory responses in bank voles infected with PUUV, revealing that virus-induced interleukin-10 promotes persistent infections by suppressing immune responses.

Snake deltavirus utilizes envelope proteins of different viruses to generate infectious particles

This study shows snake deltavirus can use various helper viruses or viral glycoproteins to generate infectious particles, expanding the known range of helper viruses beyond hepatitis B virus.

Identification of a novel deltavirus in Boa constrictor

The paper identifies a novel deltavirus, sHDV, in Boa constrictor, showing it replicates independently of HBV and spreads via vertical and horizontal transmission.