A mutation in vesicular acetylcholine transporter increases tubulin acetylation compromising axonal transport
C.-S. Kuo, V. M. Ruckmani, M. S. Khawaja, M.-C. Wang, O. Bayansan, S. N. Barmaver, P. Bhan, O. I. Wagner
This study identifies a mutation in the vesicular acetylcholine transporter (UNC-17) that increases tubulin acetylation, impairing axonal transport by disrupting interactions between UNC-104, UNC-17, and MEC-17.
bioRxiv · Jun 6, 2024Cell Biology