C.-Y. Chang

Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputs

This study shows that breast cancer cells respond differently to low and high levels of progestins, with low levels promoting proliferation through specific molecular mechanisms.

Rewiring Cancer Drivers to Activate Apoptosis

This paper introduces TCIPs, molecules that activate cell death by rewiring cancer drivers, showing efficacy against DLBCL and potential for broader therapeutic applications.

Ca2+/Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis

This study identifies CaMKK2 as a driver of tumor metastasis through a novel signaling pathway involving PDE1A, PKG1, and VASP, suggesting it as a therapeutic target for TNBC and HGSOC.

Emergent coexistence in multispecies microbial communities

The paper tests whether pairwise coexistence in microbial communities predicts coexistence in complex communities, finding that most species pairs fail to coexist when isolated.

Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells

This study shows that CaMKK2 in tumor-infiltrating NK cells suppresses apoptosis and promotes proliferation, with its expression driven by intracellular lactic acid.

Dissolvable microgel-templated macroporous hydrogels for controlled cell assembly

This paper develops a method to create cell-laden macroporous hydrogels using dissolvable microgels, enabling controlled cell assembly and secretion of growth factors.

Confined migration induces heterochromatin formation and alters chromatin accessibility

The paper shows that confined cell migration induces heterochromatin formation and alters chromatin accessibility, which affects migration speed and cellular functions.

Top-down engineering of complex communities by directed evolution

This study develops a modeling framework to explore directed evolution strategies for engineering complex microbial communities, identifying effective methods to enhance their stability and functionality.

Artificially selecting microbial communities using propagule strategies

The paper uses artificial selection experiments to compare propagule strategies in microbial communities, finding that selected communities achieve higher function than controls in two different experimental setups.

Metabolic rules of microbial community assembly

This study shows microbial community assembly is predictable from metabolic principles, with taxonomic variability explained by competitive exclusion within functional groups.

EXO70D isoforms mediate selective autophagic degradation of Type-A ARR proteins to regulate cytokinin sensitivity

Inhibition of a Selective SWI/SNF Function Synergizes with ATR Inhibitors in Cancer Cell Killing

The paper identifies small molecules that inhibit a specific repressive function of SWI/SNF complexes, which synergize with ATR inhibitors to kill cancer cells.

Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein

This paper introduces a sonogenetic method using an engineered auditory-sensing protein to control cellular activities with ultrasound, showing it can stimulate neurons in deep brain regions non-invasively.