Author

P. Biggin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

J. L. Parker· 2 shared S. Newstead· 2 shared A. Gerondopoulos· 1 shared F. A. Barr· 1 shared P. Bräuer· 1 shared S. M. Lichtinger· 1 shared T. Sobajima· 1 shared Z. Wu· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 23 mutual co-author links

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2 shared papersBiophysics

J. L. Parker

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2 papers

Recent·Most cited

The mechanism of mammalian proton-coupled peptide transporters

S. M. Lichtinger, J. L. Parker, S. Newstead, P. Biggin

This study uses molecular dynamics simulations to elucidate the conformational mechanism and proton-substrate coupling in mammalian POTs, revealing key structural differences and functional insights.

bioRxiv · Feb 4, 2024Biophysics

A baton-relay mechanism for ER retrieval signal capture and proofreading by the KDEL receptor

A. Gerondopoulos, P. Bräuer, T. Sobajima, Z. Wu, J. L. Parker, P. Biggin, F. A. Barr, S. Newstead

The paper investigates the KDEL receptor's mechanism for capturing and proofreading ER retrieval signals, revealing a baton-relay mechanism and selective proofreading steps.

bioRxiv · Mar 21, 2021Cell Biology