Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis
A. S. Riching, E. Danis, Y. Zhao, Y. Cao, C. Chi, R. Bagchi, B. Klein, H. Xu, T. Kutateladze, T. McKinsey, P. Buttrick, K. Song
The paper identifies how TGF-β signaling inhibition allows GATA4 to interact with JMJD3, promoting cardiomyogenesis by demethylating H3K27me3 at cardiac gene promoters.
bioRxiv · Feb 12, 2020Cell Biology