Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation
K. Brown, P. Y. Chew, S. Ingersoll, J. Rene Espinosa, A. Aguirre, T. Kutateladze, R. Collepardo-Guevara, X. Ren
This study reveals the scaffold-client model of PRC1 condensate assembly through phase separation, showing how CBX2 acts as a scaffold and other subunits influence condensate properties and composition.
bioRxiv · Dec 26, 2022Biochemistry