K. Song

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

Structural basis of respiratory complexes adaptation to cold temperatures

This study identifies a cold-induced conformation of respiratory complex CI:III2 using cryo-EM and simulations, revealing structural changes that enhance electron transfer efficiency in cold environments.

Targeting transcription factors through an IMiD independent zinc finger domain

This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.

1.7 GHz long-term evolution radiofrequency electromagnetic field with efficient thermal control has no effect on the proliferation of different human cell types

The study examines the effect of 1.7 GHz LTE RF-EMF on cell proliferation, finding no significant effect when thermal control is maintained, but increased proliferation when thermal control is disabled.

Selective refueling of CAR T cells using ADA1 and 1 CD26 boosts antitumor immunity

This study shows that engineering CAR T cells to co-express ADA1 and CD26 improves their antitumor activity by selectively refueling them with inosine in the tumor microenvironment.

The crystal and cryo-EM structures of PLCγ2 reveal dynamic inter-domain recognitions in autoinhibition

The paper determines crystal and cryo-EM structures of PLCγ2 in autoinhibited states and bound to FGFR1 kinase domain, revealing dynamic inter-domain interactions in autoinhibition.

Markerless motion capture estimates of lower extremity kinematics and kinetics are comparable to marker-based across 8 movements

This study compares markerless and marker-based motion capture for 8 movements, finding high agreement in ankle and knee metrics but more discrepancies in hip measurements.

Discovering SARS-CoV-2 neoepitopes and the associated TCR-pMHC recognition mechanisms by combining single-cell sequencing, deep learning, and molecular dynamics simulation techniques

This study identifies SARS-CoV-2 epitopes and their TCR recognition mechanisms using single-cell sequencing, deep learning, and molecular dynamics simulations.

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

The paper reports a cryo-EM structure of the SARS-CoV-2 postfusion spike in a membrane, revealing structural details of membrane-interacting segments.

Structure of human phagocyte NADPH oxidase in the resting state

The paper reports the cryo-EM structure of the human NOX2-p22 complex in the resting state, revealing interactions and conformational features important for its function.

Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sites

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

Cryo-EM structure of a RAS/RAF recruitment complex

The paper presents cryo-EM structures of a KRAS/BRAF/MEK1/14-3-3 complex, showing KRAS binding to BRAF's Ras-binding domain without activating it, suggesting stabilization of a pre-activation intermediate as a therapeutic target.

REST: A method for restoring signals and revealing individual macromolecule states in cryo-ET

REST is a deep learning method that restores cryo-ET density maps by denoising and compensating for missing wedge effects, enabling visualization of individual macromolecules.

Cryo-EM structures reveal a dynamic transformation process of human alpha-2-macroglobulin working as a protease inhibitor

Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

Alterations to the broad-spectrum formin inhibitor SMIFH2 improve potency

The paper tests SMIFH2 and its derivatives against human formins, finding that modifications enhance potency but do not allow distinction between conserved FH2 domains.

Memory effects and static disorder reduce information in single-molecule signals

The paper uses information-theory-based analysis to distinguish between different models of single-molecule dynamics, showing that non-Markov signals have lower entropy rates than Markov approximations.

Quantitative Structural Analysis of Influenza Virus by Cryo-electron Tomography and Convolutional Neural Networks

This paper develops a cryoET processing pipeline using CNNs to characterize the morphology and structure of influenza viruses, improving analysis throughput and enabling subtomogram averaging of glycoproteins.

Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in mediating targeted therapy dosage challenges

This study investigates how BRAF amplifications in different genomic forms enable melanoma cells to adapt to targeted therapy dose changes, revealing mechanisms of drug resistance.

Expression of the cyanobacterial F0F1 ATP synthase inhibitor Atp{Theta} depends on small basic DNA-binding proteins and differential mRNA stability

This study identifies transcriptional and posttranscriptional regulators of atpT gene expression in Synechocystis sp. PCC 6803, showing mRNA stability is the major factor controlling Atp{Theta} expression under different conditions.

Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex

This study presents the structure of the yeast nuclear pore complex using cryo-EM, revealing its functional adaptations and evolutionary links.

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

Nuclear soluble cGAS senses DNA virus infection

This study shows HSV-1 infection releases cGAS from chromatin into the nucleus, where it senses viral DNA and activates type I IFN production.

Atp{Theta} is an inhibitor of F0F1 ATP synthase to arrest ATP hydrolysis during low-energy conditions in cyanobacteria

This study identifies Atp{Theta} as an inhibitor of F0F1 ATP synthase in cyanobacteria, preventing ATP hydrolysis under low-energy conditions.

Regulation of GTPase function by autophosphorylation

This study shows autophosphorylation of small GTPases like H-RAS and K-RAS alters their nucleotide exchange and effector interactions, changing their functional behavior.

Distinct allosteric mechanisms of first-generation MsbA inhibitors

This study investigates how two first-generation MsbA inhibitors, TBT1 and G247, induce opposite allosteric effects by binding to distinct sites in the transmembrane domains.

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy

The paper shows that GDC-0077 and taselisib degrade mutant PI3K alpha via HER2-dependent mechanisms, enhancing efficacy in PIK3CA-mutant breast cancer.

Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins

This study determines the cryo-EM structures of LolCDE and reveals its mechanism for extracting triacylated lipoproteins from the cytoplasmic membrane.

Silkworm spinning: the programmed self-assembly from natural silk fibroin to superfibre

This study reveals how silkworms use metal ions and pH gradients to drive the self-assembly of silk fibroin nanofibrils into herringbone-like structures for fiber spinning.