Author

P. C. Armstrong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

H. E. Allan· 3 shared T. D. Warner· 3 shared A. Joshi· 2 shared J. A. Mitchell· 2 shared M. Crescente· 2 shared M. Mayr· 2 shared N. S. Kirkby· 2 shared A. Vadgama· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

H. E. Allan

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Author profile →

4 papers

Recent·Most cited

Multi-parameter phenotyping of platelets and characterisation of the effects of agonists using machine learning

A. Vadgama, J. Boot, H. E. Allan, C. A. Mein, P. C. Armstrong, T. D. Warner

This paper uses multi-parameter flow cytometry and machine learning to characterize platelet sub-populations and their responses to agonists, achieving high accuracy in distinguishing platelet age and activation states.

bioRxiv · Dec 8, 2023Immunology

Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic

J. A. Mitchell, M. Vinokurova, M. E. Lopes-Pires, F. Shala, P. C. Armstrong, B. Ahmetaj-Shala, Y. Elghazouli, B. Liu, Y. Zhou, C. Hao, H. Herschman, N. S. Kirkby

The paper shows lung and other tissues produce prostacyclin via fibroblasts, providing systemic anti-thrombotic protection, challenging the traditional view that endothelium is the main source.

bioRxiv · Jan 11, 2022 · PreprintPharmacology & Toxicology

Temporal in vivo platelet labelling in mice reveals age-dependent receptor expression and conservation of specific mRNAs

P. C. Armstrong, H. E. Allan, N. S. Kirkby, A. Joshi, C. Gutmann, M. Crescente, J. A. Mitchell, M. Mayr, T. D. Warner

This study uses in vivo temporal labeling to show age-dependent changes in mouse platelet function and mRNA conservation.

bioRxiv · Dec 17, 2021Physiology

Proteome and functional decline as platelets age in the circulation

H. E. Allan, M. A. Hayman, S. Marcone, M. V. Chan, M. L. Edin, T. Maffucci, A. Joshi, L. Menke, M. Crescente, M. Mayr, D. C. Zeldin, P. C. Armstrong, T. D. Warner

The paper investigates age-related changes in platelets, finding reduced protein content, altered proteomic pathways, and functional decline in older platelets.

bioRxiv · Jun 2, 2021Cell Biology