Pharmacology & ToxicologybioRxivPreprint
Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic
J. A. Mitchell, M. Vinokurova, M. E. Lopes-Pires…·N. S. Kirkby
The paper shows lung and other tissues produce prostacyclin via fibroblasts, providing systemic anti-thrombotic protection, challenging the traditional view that endothelium is the main source.