Author

C. A. Mein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:rat· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

R. Mesnage· 4 shared D. Mandrioli· 3 shared E. Bourne· 3 shared F. Belpoggi· 3 shared E. Savage· 2 shared L. Falcioni· 2 shared M. N. Antoniou· 2 shared A. Vadgama· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersPharmacology & Toxicology

R. Mesnage

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Author profile →

5 papers

Recent·Most cited

Multi-parameter phenotyping of platelets and characterisation of the effects of agonists using machine learning

A. Vadgama, J. Boot, H. E. Allan, C. A. Mein, P. C. Armstrong, T. D. Warner

This paper uses multi-parameter flow cytometry and machine learning to characterize platelet sub-populations and their responses to agonists, achieving high accuracy in distinguishing platelet age and activation states.

bioRxiv · Dec 8, 2023Immunology

Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome

R. Mesnage, S. Panzacchi, E. Bourne, C. A. Mein, M. Perry, J. Hu, J. Chen, D. Mandrioli, F. Belpoggi, M. N. Antoniou

This study shows that glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal communities in rat caecum microbiomes, with formulations causing more pronounced changes than glyphosate alone.

bioRxiv · Nov 19, 2021 · PreprintPharmacology & Toxicology

Comparative toxicogenomics of glyphosate and Roundup herbicides by mammalian stem cell-based genotoxicity assays and molecular profiling in Sprague-Dawley rats

R. Mesnage, M. Ibragim, D. Mandrioli, L. Falcioni, E. Tibaldi, F. Belpoggi, I. Brandsma, E. Bourne, E. Savage, C. A. Mein, M. N. Antoniou

This study compares the genotoxicity of glyphosate and Roundup herbicides using stem cell assays and molecular profiling in rats, finding Roundup causes more carcinogenesis-related changes.

bioRxiv · Apr 12, 2021Pharmacology & Toxicology

Multi-omics phenotyping of the gut-liver axis allows health risk predictability from in vivo subchronic toxicity tests of a low-dose pesticide mixture

R. Mesnage, M. Teixeira, D. Mandrioli, L. Falcioni, Q. R. Ducarmon, R. D. Zwittink, C. Amiel, J.-M. Panoff, E. Bourne, E. Savage, C. A. Mein, F. Belpoggi, M. Antoniou

The paper uses multi-omics analysis on pesticide-exposed rats to show metabolic and epigenetic changes in the gut-liver axis that predict health risks not detected by standard tests.

bioRxiv · Aug 25, 2020 · PreprintPharmacology & Toxicology

Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126

R. Mesnage, M. Biserni, S. Balu, C. Frainay, N. Poupin, F. Jourdan, E. Wozniak, T. Xenakis, C. A. Mein, M. A. Antoniou

This study uses transcriptomics and metabolomics to show PCB 126 exposure disrupts lipid metabolism in HepaRG cells, causing oxidative stress and altered metabolite levels.

bioRxiv · Feb 3, 2018Pharmacology & Toxicology