Author

S. Kuehne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Organism:C. elegans· 1

Frequent Co-Authors

N. P. Minton· 2 shared A. C. Lücke· 1 shared A. Donlan· 1 shared C. Brito-Silva· 1 shared C. Schwan· 1 shared D. Paredes-Sabja· 1 shared G. Cofre-Araneda· 1 shared J. L. Leslie· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

N. P. Minton

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Clostridioides difficile binary toxin binding component (CDTb) increases virulence in a hamster model

M. Simpson, T. Bilverstone, J. L. Leslie, A. Donlan, M. J. Uddin, W. Petri, N. Marin, C. Schwan, S. Kuehne, N. P. Minton, W. A. Petri

This study shows that CDTb, a component of C. difficile binary toxin, contributes to virulence by inducing inflammation and restoring virulence in a hamster model when expressed alone.

bioRxiv · Aug 3, 2021Microbiology

A novel bacteriophage with broad host-range against Clostridioides difficile ribotype 078 elucidates the phage receptor.

M. J. Whittle, T. W. Bilverstone, R. J. van Esveld, A. C. Lücke, M. M. Lister, S. Kuehne, N. P. Minton

This study isolates four novel bacteriophages against C. difficile, identifies SlpA as the receptor for one phage with broad host-range activity against RT 078 strains, and suggests a strategy for developing a broad-spectrum phage cocktail.

bioRxiv · May 26, 2021Microbiology

Clostridioides difficile spore-entry into intestinal epithelial cells contributes to recurrence of the disease

P. Castro-Cordova, P. Mora-Uribe, R. Reyes-Ramirez, G. Cofre-Araneda, J. Orozco-Aguilar, C. Brito-Silva, M. J. Mendoza-Leon, S. Kuehne, N. Minton, M. Pizarro-Guajardo, D. Paredes-Sabja

This study identifies mechanisms by which C. difficile spores enter intestinal epithelial cells, contributing to disease recurrence and suggesting therapeutic targets.

bioRxiv · Sep 11, 2020 · PreprintMicrobiology