Mechanism Driven Early Stage Identification and Avoidance of Antisense Oligonucleotides Causing TRL9 Mediated Inflammatory Responses in Bjab cells
A. J. Pollak, P. Cauntay, T. Machemer, S. Paz, S. Damle, S. P. Henry, S. A. Burel
The paper develops and validates a high-throughput Bjab cell assay to identify proinflammatory PS-ASOs by measuring Ccl22 mRNA levels, showing it replicates hPBMC assay results and provides mechanistic insights.
bioRxiv · Dec 12, 2021 · PreprintPharmacology & Toxicology