The Synergism Between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia
V. Gaidano, M. Houshmand, N. Vitale, G. Carra, A. Morotti, V. Tenace, S. Rapelli, S. Sainas, A. C. Pippione, M. Giorgis, D. Boschi, M. L. Lolli, A. Cignetti, G. Saglio, P. Circosta
This study shows that combining a DHODH inhibitor with dipyridamole induces metabolic lethality and apoptosis in AML cells, overcoming pyrimidine salvage pathway resistance.
bioRxiv · Oct 10, 2020Cancer Biology