Author

S. Sainas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

D. Boschi· 2 shared M. L. Lolli· 2 shared A. C. Pippione· 1 shared A. Calistri· 1 shared A. Cignetti· 1 shared A. Luganini· 1 shared A. Morotti· 1 shared C. Del Vecchio· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

D. Boschi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The new generation hDHODH inhibitor MEDS433 hinders the in vitro replication of SARS-CoV-2

A. Calistri, A. Luganini, V. Conciatori, C. Del Vecchio, S. Sainas, D. Boschi, M. L. Lolli, G. Gribaudo, C. Parolin

The paper identifies MEDS433, a hDHODH inhibitor, as effective against SARS-CoV-2 in vitro by blocking viral replication through hDHODH inhibition.

bioRxiv · Dec 6, 2020Microbiology

The Synergism Between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia

V. Gaidano, M. Houshmand, N. Vitale, G. Carra, A. Morotti, V. Tenace, S. Rapelli, S. Sainas, A. C. Pippione, M. Giorgis, D. Boschi, M. L. Lolli, A. Cignetti, G. Saglio, P. Circosta

This study shows that combining a DHODH inhibitor with dipyridamole induces metabolic lethality and apoptosis in AML cells, overcoming pyrimidine salvage pathway resistance.

bioRxiv · Oct 10, 2020Cancer Biology