Genomic landscape and chronological reconstruction of driver events in multiple myeloma
F. Maura, N. Bolli, N. Angelopoulos, K. J. Dawson, D. Leongamornlert, I. Martincorena, T. J. Mitchell, A. Fullam, S. Gonzalez, R. Szalat, B. Rodriguez-Martin, M. K. Samur, D. Glodzik, M. Roncador, M. Fulciniti, , P. J. Campbell
This study reconstructs the genomic evolution of multiple myeloma by analyzing 67 genomes from 30 patients and public datasets, identifying 7 subgroups defined by distinct driver mutations and chronological patterns of genomic events.
bioRxiv · Aug 12, 2018Cancer Biology