H. Avet-Loiseau

Inflamed Natural Killer cells with adhesion defects are associated with a poor prognosis in Multiple Myeloma

This study identifies CD16/CD226low NK cells with inflammatory signatures and reduced effector functions in multiple myeloma patients, correlating with poor clinical outcomes.

Integrative multi-omics identifies high risk Multiple Myeloma segment associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

The paper identifies a high-risk Multiple Myeloma subgroup using multi-omics data, linking genomic loss to dysregulated DNA repair and cell cycle pathways.

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

This study examines DNA methylation heterogeneity in multiple myeloma, linking it to transcriptomic variability and poor patient outcomes through epigenetic and structural changes.

DNA hydroxymethylation reveals transcription regulation networks and prognostic signatures in multiple myeloma

This study analyzes DNA hydroxymethylation in multiple myeloma to identify regulation networks and prognostic signatures associated with disease progression and survival.

Multiple Myeloma DREAM Challenge Reveals Epigenetic Regulator PHF19 As Marker of Aggressive Disease

The paper identifies PHF19 as a marker of aggressive multiple myeloma and shows a simple four-feature model performs as well as complex gene expression models.

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

This study reconstructs the genomic evolution of multiple myeloma by analyzing 67 genomes from 30 patients and public datasets, identifying 7 subgroups defined by distinct driver mutations and chronological patterns of genomic events.