T. J. Mitchell

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

Clonal diversification and histogenesis of malignant germ cell tumours

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

Mitochondrial fission is increased in macrophages during mROS production in response to S. pneumoniae

This study shows that mitochondrial fission in macrophages increases during mROS production in response to S. pneumoniae, linked to reduced oxidative phosphorylation and enhanced bacterial killing.

The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins

This study identifies ZFP36 and ZFP36L1 as RNA binding proteins that regulate the timing and potency of CD8+ T cell differentiation and effector function during immune response.

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

This paper identifies structural changes in a non-hemolytic pneumolysin variant that disable pore formation, enabling pneumococcus to adopt an intracellular lifestyle with reduced inflammation and increased host tolerance.

Cellular mRNA signals in human kidney tumors

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.

3D-printed moulds for image-guided surgical biopsies: an open source computational platform

This paper develops an open-source computational platform to create 3D-printed moulds for image-guided surgical biopsies, achieving accurate co-registration of imaging and tissue samples.

Mechanisms Generating Cancer Genome Complexity From A Single Cell Division Error

This study identifies a mutational cascade triggered by chromosome bridge formation that leads to chromothripsis and contributes to cancer genome complexity and sub-clonal heterogeneity.

Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours

The paper uses sequencing methods to show that cell-free tumour DNA levels are low in renal cancer but can still be informative with improved detection strategies.

The evolutionary history of 2,658 cancers

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

This study reconstructs the genomic evolution of multiple myeloma by analyzing 67 genomes from 30 patients and public datasets, identifying 7 subgroups defined by distinct driver mutations and chronological patterns of genomic events.