Author

S. Gonzalez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:whole-genome sequencing· 2 Organism:Arabidopsis· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Wohlkonig· 2 shared B. Fischer· 2 shared J. Steyaert· 2 shared S. Ballet· 2 shared W. Versees· 2 shared A. A. Sablina· 1 shared A. Alfonso· 1 shared A. Blackford· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBioengineering

A. Wohlkonig

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Nanobody CDR3 mimetics enhance SOS1-catalyzed nucleotide exchange on RAS

K. Van holsbeeck, B. Fischer, S. Gonzalez, C. Gadais, W. Versees, J. C. Martins, C. Martin, A. Wohlkonig, J. Steyaert, S. Ballet

This study shows that CDR3 mimetics can enhance SOS1-catalyzed nucleotide exchange on RAS, demonstrating functional modulation of protein-protein interactions through structural mimicry of a nanobody.

bioRxiv · Dec 9, 2022 · PreprintBioengineering

Competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

B. Fischer, T. Uchanski, A. Sheryazdanova, S. Gonzalez, A. N. Volkov, E. Brosens, T. Zogg, V. V. Kalichuk, S. Ballet, W. Versees, A. A. Sablina, E. Pardon, A. Wohlkonig, J. Steyaert

The paper introduces methods to discover Nanobodies that modulate SOS1-RAS interactions and nucleotide exchange rates, with potential applications in drug design.

bioRxiv · Dec 6, 2022 · PreprintBioengineering

Arabidopsis transcriptome responses to low water potential using high throughput plate assays

S. Gonzalez, J. Swift, A. Yaaran, J. Xu, C. Miller, N. Illouz-Eliaz, J. R. Nery, Y. Zait, W. Busch, J. R. Ecker

The paper compares transcriptional responses in Arabidopsis to different water potential reduction methods and introduces a high-throughput hard agar assay.

bioRxiv · Nov 25, 2022Plant Biology

Cellular-level phenotyping of tumor-immune microenvironment (TiME) in patients in vivo reveals distinct inflammation and endothelial anergy signatures

A. Sahu, T. Tembo, K. Kose, A. Santella, A. Alfonso, M. Li, M. Cordova, M. Gill, C. Fox, S. Gonzalez, A. W. Wang, N. R. Kurtansky, P. Chandrani, P. Kumar, S. Yin, , M. Rajadhyaksha

The paper uses in vivo cellular-level imaging to phenotype tumor-immune microenvironments, identifying distinct inflammation and endothelial anergy signatures linked to immunotherapy response.

bioRxiv · Jun 10, 2021Cancer Biology

Genomic landscape and chronological reconstruction of driver events in multiple myeloma

F. Maura, N. Bolli, N. Angelopoulos, K. J. Dawson, D. Leongamornlert, I. Martincorena, T. J. Mitchell, A. Fullam, S. Gonzalez, R. Szalat, B. Rodriguez-Martin, M. K. Samur, D. Glodzik, M. Roncador, M. Fulciniti, , P. J. Campbell

This study reconstructs the genomic evolution of multiple myeloma by analyzing 67 genomes from 30 patients and public datasets, identifying 7 subgroups defined by distinct driver mutations and chronological patterns of genomic events.

bioRxiv · Aug 12, 2018Cancer Biology

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors

A. Henssen, R. Koche, J. Zhuang, E. Jiang, C. Reed, A. Eisenberg, E. Still, I. MacArthur, E. Rodriguez-Fos, S. Gonzalez, M. Puiggros, A. Blackford, C. Mason, E. De Stanchina, M. Gonen, , A. Kentsis

This study identifies PGBD5 as an oncogenic DNA transposase in rhabdoid tumors, causing site-specific genomic rearrangements through PSS sequences and end-joining repair.

bioRxiv · Feb 23, 2017Cancer Biology