Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis
V. Miguel, J. Tituana, J. I. Herrero, L. Herrero, D. Serra, P. Cuevas, C. Barbas, D. Rodriguez-Puyol, L. Marquez-Exposito, M. Ruiz-Ortega, C. Castillo, X. Sheng, K. Susztak, M. Ruiz-Canela, J. Salas-Salvado, , S. Lamas
This study shows that overexpressing Cpt1a in renal tubular epithelial cells reduces fibrosis by restoring mitochondrial function and bioenergetics in CKD models and human patients.
bioRxiv · Feb 18, 2020Biochemistry