K. Susztak

HIV viral protein R induces loss of DCT1-type renal tubules

This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.

Renal proximal tubule cell state and metabolism are coupled by nuclear receptors

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

This study shows that overexpressing Cpt1a in renal tubular epithelial cells reduces fibrosis by restoring mitochondrial function and bioenergetics in CKD models and human patients.

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environment

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

Loss of ELK1 has differential effects on age-dependent organ fibrosis and integrin expression

This study shows that loss of ELK1 leads to age-related fibrosis in the lung and liver but not heart or kidneys, and links reduced ELK1 to cigarette smoke exposure.

Jagged1/Notch2 Controls Kidney Fibrosis via Tfam-mediated Metabolic Reprogramming

This study identifies Jag1/Notch2 as a key driver of kidney fibrosis through Tfam-mediated metabolic reprogramming in mouse models.

Comprehensive single cell RNAseq analysis of the kidney reveals novel cell types and unexpected cell plasticity

The paper uses single-cell RNA sequencing to identify novel kidney cell types and Notch-mediated plasticity in collecting duct cells, which is defective in chronic kidney disease.