Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas
S. Viragova, L. Aparicio, J. Zhao, L. E. Valencia Salazar, A. Schurer, A. Dhuri, D. Sahoo, C. A. Moskaluk, R. Rabadan, P. Dalerba
This study identifies cell-surface markers to isolate distinct cell types in ACC, shows myoepithelial-like cells as progenitors of ductal-like cells, and demonstrates RA signaling modulation as a therapeutic strategy.
bioRxiv · Jan 19, 2022Cancer Biology